Function agnoprotein

• Overexpression:

• G2/M arrest and decline cyclin A and B

• Knock-down

• Reduces VP1 and LT-Ag expression

• Mutation :

• Mutation of phosphosites reduces viral load
• Deficient in DNA (JC)

• Deletion

• Abrogates viral replication
• Slower assembly minichromosome (SV40)