FMDV

• • FMDV enters via respiratory tract, systemic spread
  • No canyon: RGD motifs in VP1 ~ integrin receptors.
  • IRES :
  • • • requires Murine Proliferation Associated Protein 1 (Mpp-1) which binds IRES central domain
      • acts synergistically with Ptb to increase binding of eIF4F.
      • may determine tropism for IRES function:
      • • => TMEVFMDV-IRES affects brain replication