PCNA and viral infection

• Viral PCNA-mimics :

• HCMV UL44, HSV UL42, EBV BMRF1
• Plant virus TYLCSV Rep/Ren = assembly of plant replication complex close to virus origin of replication

• Viral interference with PIPs

• E7 HPV16 prevents PCNA-p21 interaction
• JC LT-Ag : YB-1 (cisplatin-induced NER)
• JC Agno : p21, Ku70/Ku80