Remedies

• Mycophenolic acid and ribavirin

• • • in MK cells : defective vRNA production; reduction of viral replicas activity
    • inhibition of inosine monophosphate dehydrogenase, depleting the intracellular GTP pool (guanosine reverses)
    • RBV may compete with guanine-nt precursors in vRNA translation, replication and 5' capping

• NO downregulates RdRp, hence RNA synthesis

• ZX-2401

• Mosquito control, supportive treatment (fluids)