Disease

• Dengue fever :

• • • headache, fever, retro-orbital pain, myalgia, arthralgia, rash

• Dengue hemorrhagic fever :

• • • vascular permeability, thrombocytopenia, hemorrhagic manifestations

• Dengue shock syndrome :

• • • when fluid leakage into interstitial spaces lead to shock (and death if untreated)

• leading cause of pediatric hospitalization

• • • Risc factors : age, immune status, genetic bg, viral serotype, 2nd heterologous serotype infection (DHF/DSS)