other pROTEINS

• Integral membrane protein M and envelope glycoprotein :

• • • Translated by membrane-bound polyribosomes
    • Insertion in membrane = similar to togaviruses
    • Protein M = N-terminal signal sequence (insertion into ER)

• NS1 :

• • • binds to complement : contributes to protective immunity by lysing infected cells.
    • Ab against precursor NS1 protect animals against infection

• NS3 target for attachment by CTLs.