Cytopathology and disease

• • Three serotypes :
  • • • differ in antigenic properties of viral structural proteins
      • serotype 3 -> increased risc of paralysis
  • Fecal contamination of food and water
  • No common group-specific Ag; but antigenic sharing and type-specific Ag
  • Outcome of poliovirus infection depends on virulence of strain, size of infecting dose, immune status of host
  • Transgenic mice expressing the human Pvr, or defective in a component of the Immune System