IRES

• Internal Ribosome Entry Site :

• • @ 5' UTR
  • promotes internal binding of the 40S ribosomal su
  • 5 different types of IRES :
  • • • Type 1: enteroviruses, rhinoviruses : initiation codon is 50-100nt past 3' end of IRES
      • Type 3: hepatitis A : initiation codon is 50-100nt past 3' end of IRES
      • Type 2: cardioviruses and aphtoviruses
      • Type 5: ends in initiation codon (not AUG)
      • Type 4: 3' end of IRES extends beyond AUG