Specialties

• VPg :

• • • replaces 5' methylated cap from cellular mRNA,
    • serves as primer for RNA replication

• Leader sequence :

• • • takes a complex structure via intramolecular base pairing called IRES

• Normal Kozak rules don't apply :

• • • AUG that begins ORF is preceded by 8 other AUG triplets that are not utilized for initiation of translation

• inhibits cellular protein synthesis ~> host shut-off