Coronaviruses

• Corona : crown

• • • • porcine, feline, canine, bovine, murine => severe disease

• > 15 types : respiratory and enteric (intestinal) diseases.

• Viral Characteristics:

• • Spherical but slightly pleomorphic, 120-140 nm.
  • Envelope projections : obvious, distinct, evenly spaced
  • Leader, 3' pseudoknot
  • 5 ORFs ; ≥ 6 subgenomic RNA's
  • Replicase ~ 70% of ORF