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MK5 - Challenges
- Does a GST (HA/EGFP) tag sterically prevent access to catalytic sites on MK5 ? Can we model this ?
- Can we model the C-terminal part of MK5 ?
- What are the most likely binding sites for MK5 on an energetic point of view ?
- Are these sites complementary or do they fit the bindingssites of the putative substrates or interaction partners (PKA; PKC; PKD; TH, PLA2)?
- Can we make an MD simulation on MK5 and an interaction partner (e.g. PKA, TH) ?