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MK5 - The Protein

K51E : kinase dead :
- no activ by MKK6E/E and p38.
- but p38 can phosphorylate); T182D,S212

p38 docking site : only moderately increases activity:

T182A : activity= regulatory phosphorylation site for p38alpha/beta,

L337A : renders the protein constitutively activated