Phospho-Regulation

• cAMP, FSK, ALF3 decrease cPLA2 activity caused by PKC, MAPK activators

• PKA, PKC, MAPK directly => PLA2 but may also phosphorylate PLA2 inhib prot (lipocortins, annexins) and PLA2 activ prot..

• PKA, MAPK, PKC, cAMP vs cellular injury.