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Phosphorylation motifs
Activation loop :
- phosphorylation required prior to catalytic activity
- near entrance of active site in kinases
Turn motif :
- Thr res and adjacent residues
- stabilizing the kinase core
- binding with chaperones
Hydrophobic motif :
- ser/thr flanked by hydrophobic res
- docking site for PDK-1
Consensus: S/TXK/R ; K/RXXS/T(XK/R); K/RXS/T(XK/R)