First page Back Continue Last page Overview Graphics
What ?
Protein kinase C
- ABC kinases:
- 3 conserved phosphorylation motifs
- 2nd messengers allosterically regulate enzymatic activity
History: first PKCs discovered
Evolution : yeast, C.elegans, humans
Family :
- at least 12 different subtypes, divided into 3 classes
- isotypes differ in localization and req. for cofactors