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Summary
- PKC= Protein kinase C
- 3 subclasses: different cofactor roles
Phosphorylation occurs first, allosteric regulation afterwards
3 mechanisms in allosteric regulation: activation loop is unmasked, affinity PDK1, chaperones for sustaining signaling lifetime
RTKs and GPCRs induce PKC responses
PKC responses activate other pathways !
Dysregulation in neurological disorders and some cancers