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Summary
- MAPK = Mitogen Activated protein kinase
MAPK module: MAPKKK, MAPKK, MAPK
3 main MAPK classes: ERK, JNK,p38 with distinct phosphorylation motifs and activation patterns ..
Scaffold proteins help in protein interactions and optimisation of signal transduction ..
Disregulation might result in severe diseases ..
Signaling complexity: MAPK pathway doesn't stand alone ..