Summary – Paper 1

• PKA interacts with MK5, but not MK2 in vitro and in vivo

• PKA phosphorylates, activates and induces nuclear export of MK5
• Nuclear export requires kinase activity of PKA and MK5 and nuclear entry of PKA
• Both MK5 and PKA are required to induce F-actin rearrangements in response to FSK stimulation